Already well-known as Dr. Doug Ross in the TV Series ER, as well as some best-forgotten early film parts, such as Return of the Killer Tomatoes! (1988). This actor has appeared in a run of successful films during the past decade. His cameo role in Spy Kids 3D: Game Over (2003) has been discounted here. He also provided voices for the animated South Park: Bigger, Longer & Uncut (1999) and the title role in the forthcoming The Fantastic Mr. Fox (2009).

George Clooney