In leukemia cutis (leukemia infiltrates of the skin), the chronic lymphocytic leukemia subtype, skin lesions occur in approximately 25% of patients. Skin lesions are uncommon in the acute lymphocytic leukemia subtype. Clinically, the patients present with red papules, plaques, and nodules. Tumors and larger nodules may be seen in 10 to 50% of patients. Although leukemic skin lesions can occur anywhere, the head, neck, trunk, and especially the face appear to be the most common locations, as seen in this man. This patient’s case is so profound, that it has been referred to has ‘leonine face’ of leukemia cutis. The cutaneous lesions can appear at any time, but they tend to occur later in the course of the disease.

Reference: Atlas of Dermatology, by Gernot Rassner, Lea & Febiger, Publisher, 3rd Editition, page 189.

For additional information, please see the eMedicine article on leukemia cutis.

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