Psoriasis Biologics Tables
Table 1. Meements Used to Determine Response to Psoriasis Therapiesasur
Measurement Tool
Definition
Psoriasis Area and Severity Index (PASI)
Measures 4 body areas (head, trunk, upper extremities, lower extremities) for the extent and severity of psoriasis. PASI score denotes percent improvement from baseline (eg, PASI 75).
Evaluate
Scale
Erythema
Induration
· Score is weighted by
- Severity
- Body surface area (BSA) affected
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Table 1.
Meements Used to Determine Response to Psoriasis
Therapiesasur |
Measurement
Tool |
Definition |
Psoriasis Area and
Severity Index (PASI) |
Measures 4 body areas
(head, trunk, upper extremities, lower extremities) for the extent and
severity of psoriasis. PASI
score denotes percent improvement from baseline (eg, PASI
75).
·
Evaluate |
·
Score is weighted
by |
-Scale |
-
Severity |
-Erythema |
-
Body surface area (BSA)
affected |
-
Induration |
|
|
Target Lesion
Assessment |
Measures an identified
lesion at baseline and then at designated time points throughout the trial
period for:
·
Plaque elevation (0 = none to 4 = very
severe) |
·
Scaling (0 = none to 4 = very
severe) |
·
Erythema (0 = none to 4 = very
severe) |
·
Global assessment (0 = none to 4 = very
severe psoriasis) |
|
BSA |
Measurement of the
percentage of BSA involved; ranges from mild (less than 2% BSA), to
moderate (2%-10% BSA), to severe (greater than 10%
BSA) |
Physician’s Global
Assessment (PGA) |
A 6-category scale
ranging from very severe to clear indicating physician’s overall
assessment of the psoriasis severity at one time point, focusing on
plaque, scaling, and erythma. |
Health Assessment
Questionnaire (HAQ) |
A validated
self-administrated questionnaire, which can also be given face-to-face in
a clinical setting or in a telephone interview format by trained outcome
assessors. The Disability
Index, part of the HAQ, includes 8 categories of assessment relative to
the patient’s ability to perform activities.
·
Dressing and
grooming |
·
Hygiene |
·
Arising |
·
Reach |
·
Eating |
·
Grip |
·
Walking |
·
Common daily
activities |
|
Dermatology Life Quality
Index (DLQI) |
10-item
dermatology-specific questionnaire; scores range from 0-30, with higher
scores indicating worse quality of life.
Address:
·
Daily
activities |
·
Leisure |
·
Treatment-related
distress |
·
Work or
school |
·
Personal
relationships |
·
Symptoms |
·
Feelings |
|
|
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