Psoriasis Biologics Tables

Table 1. Meements Used to Determine Response to Psoriasis Therapiesasur

Measurement Tool

 Definition

 

Psoriasis Area and Severity Index (PASI)

 

Measures 4 body areas (head, trunk, upper extremities, lower extremities) for the extent and severity of psoriasis.  PASI score denotes percent improvement from baseline (eg, PASI 75).

·  Evaluate

· Score is weighted by

-Scale

-    Severity

-Erythema

-    Body surface area (BSA) affected

-    Induration

 

 

Target Lesion Assessment

 

Measures an identified lesion at baseline and then at designated time points throughout the trial period for:

·  Plaque elevation (0 = none to 4 = very severe)

·  Scaling (0 = none to 4 = very severe)

·  Erythema (0 = none to 4 = very severe)

·  Global assessment (0 = none to 4 = very severe psoriasis)

 

BSA

 

Measurement of the percentage of BSA involved; ranges from mild (less than 2% BSA), to moderate (2%-10% BSA), to severe (greater than 10% BSA)

Physician’s Global Assessment (PGA)

A 6-category scale ranging from very severe to clear indicating physician’s overall assessment of the psoriasis severity at one time point, focusing on plaque, scaling, and erythma.

 

Health Assessment Questionnaire (HAQ)

 

A validated self-administrated questionnaire, which can also be given face-to-face in a clinical setting or in a telephone interview format by trained outcome assessors.  The Disability Index, part of the HAQ, includes 8 categories of assessment relative to the patient’s ability to perform activities.

·  Dressing and grooming

·  Hygiene

·  Arising

·  Reach

·  Eating

·  Grip

·  Walking

·  Common daily activities

Dermatology Life Quality Index (DLQI)

10-item dermatology-specific questionnaire; scores range from 0-30, with higher scores indicating worse quality of life.  Address:

·  Daily activities

·  Leisure

·  Treatment-related distress

·  Work or school

·  Personal relationships

·  Symptoms

·  Feelings

 


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