Psoriasis Biologics Tables

Table 1. Meements Used to Determine Response to Psoriasis Therapiesasur

Measurement Tool

Definition

Psoriasis Area and Severity Index (PASI)
Measures 4 body areas (head, trunk, upper extremities, lower extremities) for the extent and severity of psoriasis. PASI score denotes percent improvement from baseline (eg, PASI 75).
Evaluate
  • Scale
  • Erythema
  • Induration
  • · Score is weighted by - Severity - Body surface area (BSA) affected
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    Table 1. Meements Used to Determine Response to Psoriasis Therapiesasur

    Measurement Tool

     Definition

     

    Psoriasis Area and Severity Index (PASI)

     

    Measures 4 body areas (head, trunk, upper extremities, lower extremities) for the extent and severity of psoriasis.  PASI score denotes percent improvement from baseline (eg, PASI 75).

    ·  Evaluate

    · Score is weighted by

    -Scale

    -    Severity

    -Erythema

    -    Body surface area (BSA) affected

    -    Induration

     

     

    Target Lesion Assessment

     

    Measures an identified lesion at baseline and then at designated time points throughout the trial period for:

    ·  Plaque elevation (0 = none to 4 = very severe)

    ·  Scaling (0 = none to 4 = very severe)

    ·  Erythema (0 = none to 4 = very severe)

    ·  Global assessment (0 = none to 4 = very severe psoriasis)

     

    BSA

     

    Measurement of the percentage of BSA involved; ranges from mild (less than 2% BSA), to moderate (2%-10% BSA), to severe (greater than 10% BSA)

    Physician’s Global Assessment (PGA)

    A 6-category scale ranging from very severe to clear indicating physician’s overall assessment of the psoriasis severity at one time point, focusing on plaque, scaling, and erythma.

     

    Health Assessment Questionnaire (HAQ)

     

    A validated self-administrated questionnaire, which can also be given face-to-face in a clinical setting or in a telephone interview format by trained outcome assessors.  The Disability Index, part of the HAQ, includes 8 categories of assessment relative to the patient’s ability to perform activities.

    ·  Dressing and grooming

    ·  Hygiene

    ·  Arising

    ·  Reach

    ·  Eating

    ·  Grip

    ·  Walking

    ·  Common daily activities

    Dermatology Life Quality Index (DLQI)

    10-item dermatology-specific questionnaire; scores range from 0-30, with higher scores indicating worse quality of life.  Address:

    ·  Daily activities

    ·  Leisure

    ·  Treatment-related distress

    ·  Work or school

    ·  Personal relationships

    ·  Symptoms

    ·  Feelings

     


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